Journal: Diagnostics

Article Title: COVID-19 Infection-Related Coagulopathy and Viscoelastic Methods: A Paradigm for Their Clinical Utility in Critical Illness

doi: 10.3390/diagnostics10100817

Figure Lengend Snippet: Studies assessing the hemostatic profiles in critically ill COVID-19 patients by viscoelastic methods.

Article Snippet: Collett et al., 2020 [ ] , COVID-19 ICU (6) , ROTEM (EXTEM, INTEM, FIBTEM) , A10, CFT, MCF, ML , Reference ranges , Hypercoagulability with minimal fibrinolysis , Thromboprophylaxis , Three patients developed VTE.

Techniques: FIBTEM Assay, Infection

Journal: Journal of Clinical Medicine

Article Title: Comparison of Two Viscoelastic Testing Devices in a Parturient Population

doi: 10.3390/jcm13030692

Figure Lengend Snippet: Comparison of extrinsically stimulated assays between ClotPro ® and ROTEM ® . ( A ): clotting time; ( B ): clot firmness after 5 min (A5 value); and ( C ): clot firmness after 10 min (A10 value); ( D ): maximal clot firmness (MCF value). On the left: Fit plot with a regression line. The blue area around the regression line represents 95% confidence limits for the regression line. The p -value and Pearson’s correlation coefficient “r” are in the lower right corner. In the middle: Bland–Altman plot of the absolute values. On the right: Bland–Altman plot of the relative values. The solid black line indicates zero difference; the red solid line represents the actual mean bias between the ClotPro ® and ROTEM ® parameters; the dashed lines represent the 95% limits of acceptance (95% LOA); the dotted line represents the 99% LOA; and the blue line represents the regression line for the difference between ClotPro ® and ROTEM ® . The numeric values of the mean bias and of the lower and upper 95% LOA are given in the bottom right corner. The clotting times are measured in seconds, and the clot firmness is measured in mm amplitude, respectively.

Article Snippet: PT < 100% vs. ROTEM ® EXTEM CT [s] , 29 vs. 602 , 0.6748 (0.59–0.76) , 49 s , 0.31 , 82.8% , 47.8% , 0.07 , 0.93.

Techniques: Comparison, Coagulation

Journal: Journal of Clinical Medicine

Article Title: Comparison of Two Viscoelastic Testing Devices in a Parturient Population

doi: 10.3390/jcm13030692

Figure Lengend Snippet: Comparison of intrinsically stimulated assays between ClotPro ® and ROTEM ® . ( A ): clotting time; ( B ): clot firmness after 5 min (A5 value); ( C ): clot firmness after 10 min (A10 value); and ( D ): maximal clot firmness (MCF value). On the left: Fit plot with a regression line. The blue area around the regression line represents the 95% confidence limits for the regression line. The p -value and Pearson’s correlation coefficient “r” are in the lower right corner. In the middle: Bland–Altman plot of the absolute values. On the right: Bland–Altman plot of the relative values. The solid black line indicates zero difference; the red solid line represents the actual mean bias between the ClotPro ® and ROTEM ® parameters; The dashed lines represents the 95% limits of acceptance (95% LOA); the dotted line represents the 99% LOA; and the blue line represents the regression line for the difference between ClotPro ® and ROTEM ® . The numeric values of the mean bias and of the lower and upper 95% LOA are given in the bottom right corner. The clotting times are measured in seconds, and the clot firmness is measured in mm amplitude, respectively.

Article Snippet: PT < 100% vs. ROTEM ® EXTEM CT [s] , 29 vs. 602 , 0.6748 (0.59–0.76) , 49 s , 0.31 , 82.8% , 47.8% , 0.07 , 0.93.

Techniques: Comparison, Coagulation

Journal: Journal of Clinical Medicine

Article Title: Comparison of Two Viscoelastic Testing Devices in a Parturient Population

doi: 10.3390/jcm13030692

Figure Lengend Snippet: Comparison of fibrin polymerization assays between ClotPro ® and ROTEM ® . ( A ): clot firmness after 5 min (A5 value); ( B ): clot firmness after 10 min (A10 value); and ( C ): maximal clot firmness (MCF value). On the left: Fit plot with a regression line. The blue area around the regression line represents the 95% confidence limits for the regression line. The p -value and Pearson’s correlation coefficient “r” are located in the lower right corner. In the middle: Bland–Altman plot of the absolute values. On the right: Bland–Altman plot of the relative values. The solid black line indicates zero difference; the red solid line represents the actual mean bias between the ClotPro ® and ROTEM ® parameters; the dashed lines represents the 95% limits of acceptance (95% LOA); the dotted line represents the 99% LOA; and the blue line represents the regression line for the difference between ClotPro ® and ROTEM ® . The numeric values of the mean bias and of the lower and upper 95% LOA are given in the bottom right corner. The clotting times are measured in seconds, and the clot firmness is measured in mm amplitude, respectively.

Article Snippet: PT < 100% vs. ROTEM ® EXTEM CT [s] , 29 vs. 602 , 0.6748 (0.59–0.76) , 49 s , 0.31 , 82.8% , 47.8% , 0.07 , 0.93.

Techniques: Comparison, Coagulation

Journal: Journal of Clinical Medicine

Article Title: Comparison of Two Viscoelastic Testing Devices in a Parturient Population

doi: 10.3390/jcm13030692

Figure Lengend Snippet: Cutoff calculations for ROTEM ® and ClotPro ® parameters based on standard laboratory values.

Article Snippet: PT < 100% vs. ROTEM ® EXTEM CT [s] , 29 vs. 602 , 0.6748 (0.59–0.76) , 49 s , 0.31 , 82.8% , 47.8% , 0.07 , 0.93.

Techniques: FIBTEM Assay

Journal: Journal of Clinical Medicine

Article Title: Comparison of Two Viscoelastic Testing Devices in a Parturient Population

doi: 10.3390/jcm13030692

Figure Lengend Snippet: Receiver operating characteristics (ROC) curve of the VAH parameters for defined laboratory cutoffs. Low PT = PT < 100 s; low fibrinogen = fibrinogen < 4 g/L; low platelets = platelet count < 150/nL; CP = ClotPro ® ; R = ROTEM ® ; PT = prothrombin time and PC = platelet contribution.

Article Snippet: PT < 100% vs. ROTEM ® EXTEM CT [s] , 29 vs. 602 , 0.6748 (0.59–0.76) , 49 s , 0.31 , 82.8% , 47.8% , 0.07 , 0.93.

Techniques:

Journal: Cureus

Article Title: Viscoelastometry to Manage Bleeding in Liver Disease

doi: 10.7759/cureus.41401

Figure Lengend Snippet: Studies evaluating viscoelastic testing as a predictor of bleeding in liver disease. ACLF = acute-on-chronic liver failure; CT = clotting time; FFP = fresh frozen plasma; MCF = maximal clot firmness; RBC = red blood cell; TXA = tranexamic acid; SCT = standard coagulation tests

Article Snippet: Examples of tests employed by two instruments, ROTEM and ClotPro, in the setting of liver disease are the EXTEM (ROTEM) and EX-test (ClotPro) that test the extrinsic pathway, INTEM (ROTEM) and IN-test (ClotPro) that test the intrinsic pathway, FIBTEM (ROTEM) and FIB-test (ClotPro) that assess fibrinogen contribution, and APTEM (ROTEM) and AP-test (ClotPro) that evaluate fibrinolysis.

Techniques: Coagulation, Clinical Proteomics, Transplantation Assay, FIBTEM Assay, Virus

Journal: Cureus

Article Title: Viscoelastometry to Manage Bleeding in Liver Disease

doi: 10.7759/cureus.41401

Figure Lengend Snippet: Studies investigating viscoelastic testing goal-directed algorithms in liver transplantation. CT = clotting time; FFP = fresh frozen plasma; Hb = haemoglobin; INR = international normalised ratio; MA = maximum amplitude; MCF = maximal clot firmness; RBC = red blood cell; RCT = randomised control trial; R time = reaction time; TEG = thromboelastograpthy; TXA = tranexamic acid; SCT = standard coagulation tests

Article Snippet: Examples of tests employed by two instruments, ROTEM and ClotPro, in the setting of liver disease are the EXTEM (ROTEM) and EX-test (ClotPro) that test the extrinsic pathway, INTEM (ROTEM) and IN-test (ClotPro) that test the intrinsic pathway, FIBTEM (ROTEM) and FIB-test (ClotPro) that assess fibrinogen contribution, and APTEM (ROTEM) and AP-test (ClotPro) that evaluate fibrinolysis.

Techniques: Transplantation Assay, Coagulation, Clinical Proteomics, Control, Concentration Assay, FIBTEM Assay, Lysis

Journal: Journal of Cardiothoracic Surgery

Article Title: Factors affecting postoperative blood loss in children undergoing cardiac surgery

doi: 10.1186/1749-8090-9-32

Figure Lengend Snippet: Coagulation parameters based on age and the presence of cyanotic disease. (A) Fibrinogen levels measured using the Clauss method at baseline and after cardiopulmonary bypass (CPB) (p < 0.001). (B) Platelet count at baseline and after CPB (p < 0.001). (C) Maximal clot firmness obtained on FIBTEM after CPB. (D) Maximal clot firmness obtained on EXTEM after CPB. ***p < 0.001 comparing < 1 month and all other groups with cyanotic and non-cyanotic diseases, #p < 0.01 comparing < 1 month and all other groups with cyanotic diseases. Blue, cyanotic patients; red, non-cyanotic patients; clear symbols represent baseline tests; and full symbols represent post-CPB tests.

Article Snippet: Ten minutes after protamine administration, blood samples were drawn to measure platelet count, fibrinogen plasma concentration (Claus method), and parameters determined by the EXTEM and FIBTEM tests on ROTEM® (ROTEM®, TEM® International GmbH, Munich, Germany).

Techniques: Coagulation, FIBTEM Assay

Journal: Cureus

Article Title: Thromboelastography in the Perioperative Period: A Literature Review

doi: 10.7759/cureus.39407

Figure Lengend Snippet: Studies of TEG in trauma perioperative settings TEG: thromboelastography; TEG-MA: TEG with maximum amplitude; rTEG; rapid thromboelastography; tPA-TEG: tissue plasminogen activator; TEG-PM: TEG with platelet mapping; TBI: traumatic brain injury; VTE: venous thromboembolism; ROTEM: rotational thromboelastometry; MTP: massive transfusion protocol

Article Snippet: Abuelkasem et al., 2016 [ ] , 36 US liver transplant patients , Intraoperative liver transplant , TEG R-time; ROTEM CT (INTEM-CT and EXTEM-CT) , Coagulopathy , INTEM-CT and EXTEM-CT were effective predictors of coagulopathy, but TEG-R was not.

Techniques: Coagulation, Comparison

Journal: Cureus

Article Title: Thromboelastography in the Perioperative Period: A Literature Review

doi: 10.7759/cureus.39407

Figure Lengend Snippet: Studies of TEG in obstetric perioperative settings TEG: thromboelastography; TEG-MA: TEG with maximum amplitude

Article Snippet: Abuelkasem et al., 2016 [ ] , 36 US liver transplant patients , Intraoperative liver transplant , TEG R-time; ROTEM CT (INTEM-CT and EXTEM-CT) , Coagulopathy , INTEM-CT and EXTEM-CT were effective predictors of coagulopathy, but TEG-R was not.

Techniques: Coagulation

Journal: Cureus

Article Title: Thromboelastography in the Perioperative Period: A Literature Review

doi: 10.7759/cureus.39407

Figure Lengend Snippet: Studies of TEG in orthopedic perioperative settings TEG: thromboelastography; TEG-PM: TEG with platelet mapping; TEG-MA: TEG with maximum amplitude; VTE: Venous thromboembolism

Article Snippet: Abuelkasem et al., 2016 [ ] , 36 US liver transplant patients , Intraoperative liver transplant , TEG R-time; ROTEM CT (INTEM-CT and EXTEM-CT) , Coagulopathy , INTEM-CT and EXTEM-CT were effective predictors of coagulopathy, but TEG-R was not.

Techniques: Coagulation, Infection

Journal: Cureus

Article Title: Thromboelastography in the Perioperative Period: A Literature Review

doi: 10.7759/cureus.39407

Figure Lengend Snippet: Studies of TEG in miscellaneous perioperative settings TEG: thromboelastography; TEG-PM: TEG with platelet mapping; TEG-MA: TEG with maximum amplitude; ROTEM: rotational thromboelastometry; aPTT: activated partial thromboplastin time

Article Snippet: Abuelkasem et al., 2016 [ ] , 36 US liver transplant patients , Intraoperative liver transplant , TEG R-time; ROTEM CT (INTEM-CT and EXTEM-CT) , Coagulopathy , INTEM-CT and EXTEM-CT were effective predictors of coagulopathy, but TEG-R was not.

Techniques: Inhibition, Control, Ligation, Coagulation, Lysis